Clonality, recombination, and hybridization in the plumbing-inhabiting human pathogen Fusarium keratoplasticum inferred from multilocus sequence typing.

ABSTRACT:

Background

Recent work has shown that Fusarium species and genotypes most commonly associated with human infections, particularly of the cornea (mycotic keratitis), are the same as those most commonly isolated from plumbing systems. The species most dominant in plumbing biofilms is Fusarium keratoplasticum, a cosmopolitan fungus known almost exclusively from animal infections and biofilms. To better understand its diversity and population dynamics, we developed and utilized a nine-locus sequence-based typing system to make inferences about clonality, recombination, population structure, species boundaries and hybridization.

Results

High levels of genetic diversity and evidence for recombination and clonality were detected among 75 clinical and 156 environmental isolates of F

SUBMITTER: Short DP 

PROVIDER: S-EPMC4026394 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature