Oral vaccination with heat inactivated Mycobacterium bovis activates the complement system to protect against tuberculosis.

ABSTRACT: Tuberculosis (TB) remains a pandemic affecting billions of people worldwide, thus stressing the need for new vaccines. Defining the correlates of vaccine protection is essential to achieve this goal. In this study, we used the wild boar model for mycobacterial infection and TB to characterize the protective mechanisms elicited by a new heat inactivated Mycobacterium bovis vaccine (IV). Oral vaccination with the IV resulted in significantly lower culture and lesion scores, particularly in the thorax, suggesting that the IV might provide a novel vaccine for TB control with special impact on the prevention of pulmonary disease, which is one of the limitations of current vaccines. Oral vaccination with the IV induced an adaptive antibody response and activation of the innate immune response in

SUBMITTER: Beltran-Beck B 

PROVIDER: S-EPMC4026474 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature