PRKCA polymorphism changes the neural basis of episodic remembering in healthy individuals.

ABSTRACT: Everyday functioning relies on episodic memory, the conscious retrieval of past experiences, but this crucial cognitive ability declines severely with aging and disease. Vulnerability to memory decline varies across individuals however, producing differences in the time course and severity of memory problems that complicate attempts at diagnosis and treatment. Here we identify a key source of variability, by examining gene dependent changes in the neural basis of episodic remembering in healthy adults, targeting seven polymorphisms previously linked to memory. Scalp recorded Event-Related Potentials (ERPs) were measured while participants remembered words, using an item recognition task that requires discrimination between studied and unstudied stimuli. Significant differences were found a

SUBMITTER: MacLeod CA 

PROVIDER: S-EPMC4026476 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature