New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

ABSTRACT: The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to) a thousand-fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.

SUBMITTER: Friggeri L 

PROVIDER: S-EPMC4027138 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature