Tuning RNA Interference by Enhancing siRNA/PAZ Recognition.

ABSTRACT: Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.

SUBMITTER: Gaglione M 

PROVIDER: S-EPMC4027432 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature