Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core.

ABSTRACT: Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate.

SUBMITTER: Bae IH 

PROVIDER: S-EPMC4027583 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature