Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.

ABSTRACT: Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an original approach to treat the cognitive decline in patients with Alzheimer's disease. A series of naphthyl-fused 5-membered lactams were identified as a new class of M1 positive allosteric modulators and were found to possess good potency and in vivo efficacy.

SUBMITTER: Yang ZQ 

PROVIDER: S-EPMC4027734 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature