Ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases.

ABSTRACT:

Background

Understanding the relationship between the millions of functional DNA elements and their protein regulators, and how they work in conjunction to manifest diverse phenotypes, is key to advancing our understanding of the mammalian genome. Next-generation sequencing technology is now used widely to probe these protein-DNA interactions and to profile gene expression at a genome-wide scale. As the cost of DNA sequencing continues to fall, the interpretation of the ever increasing amount of data generated represents a considerable challenge.

Results

We have developed ngs.plot - a standalone program to visualize enrichment patterns of DNA-interacting proteins at functionally important regions based on next-generation sequencing data. We demonstrate that ngs.plot is not o

SUBMITTER: Shen L 

PROVIDER: S-EPMC4028082 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature