Normal fibroblasts induce E-cadherin loss and increase lymph node metastasis in gastric cancer.

ABSTRACT:

Background

A tumor is considered a heterogeneous complex in a three-dimensional environment that is flush with pathophysiological and biomechanical signals. Cell-stroma interactions guide the development and generation of tumors. Here, we evaluate the contributions of normal fibroblasts to gastric cancer.

Methodology/principal findings

By coculturing normal fibroblasts in monolayers of BGC-823 gastric cancer cells, tumor cells sporadically developed short, spindle-like morphological characteristics and demonstrated enhanced proliferation and invasive potential. Furthermore, the transformed tumor cells demonstrated decreased tumor formation and increased lymphomatic and intestinal metastatic potential. Non-transformed BGC-823 cells, in contrast, demonstrated primary tumor for

SUBMITTER: Xu W 

PROVIDER: S-EPMC4028202 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature