1H NMR-based profiling reveals differential immune-metabolic networks during influenza virus infection in obese mice.

ABSTRACT: Obese individuals are at greater risk for death from influenza virus infection. Paralleling human evidence, obese mice are also more susceptible to influenza infection mortality. However, the underlying mechanisms driving greater influenza severity in the obese remain unclear. Metabolic profiling has been utilized in infectious disease models to enhance prognostic or diagnostic methods, and to gain insight into disease pathogenesis by providing a more global picture of dynamic infection responses. Herein, metabolic profiling was used to develop a deeper understanding of the complex processes contributing to impaired influenza protection in obese mice and to facilitate generation of new explanatory hypotheses. Diet-induced obese and lean mice were infected with influenza A/Puerto Rico/8/34.

SUBMITTER: Milner JJ 

PROVIDER: S-EPMC4028207 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature