Clinical and pathologic presentation in Parkinson's disease by apolipoprotein e4 allele status.

ABSTRACT:

Background

Apolipoprotein (APOE) e4 allele status has been linked to clinical presentation and progression in Alzheimer's disease; however, evidence for a role of APOE e4 in Parkinson's disease (PD) remains largely inconclusive. In this analysis we explored potential significant associations between APOE e4 allele status and characteristics of clinical presentation in patients with PD.

Methods

Data came from 424 subjects evaluated using the Uniform Data Set (UDS) assessment collected by the National Alzheimer's Coordinating Center. Subjects had a known year of diagnosis of PD and experienced change in motor function prior to any change in cognition. Linear and logistic regression were used to model the association between APOE e4 carrier status and clinical characteristics i

SUBMITTER: Monsell SE 

PROVIDER: S-EPMC4028373 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature