A bottom-up approach to understanding protein layer formation at solid-liquid interfaces.

ABSTRACT: A common goal across different fields (e.g. separations, biosensors, biomaterials, pharmaceuticals) is to understand how protein behavior at solid-liquid interfaces is affected by environmental conditions. Temperature, pH, ionic strength, and the chemical and physical properties of the solid surface, among many factors, can control microscopic protein dynamics (e.g. adsorption, desorption, diffusion, aggregation) that contribute to macroscopic properties like time-dependent total protein surface coverage and protein structure. These relationships are typically studied through a top-down approach in which macroscopic observations are explained using analytical models that are based upon reasonable, but not universally true, simplifying assumptions about microscopic protein dynamics. Conclus

SUBMITTER: Kastantin M 

PROVIDER: S-EPMC4028386 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature