The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice.

ABSTRACT:

Background

The liver plays a major role in regulating metabolic homeostasis and is vital for nutrient metabolism. Identifying the genetic factors regulating these processes could lead to a greater understanding of how liver function responds to a high-fat diet and how that response may influence susceptibilities to obesity and metabolic syndrome. In this study we examine differences in hepatic gene expression between the LG/J and SM/J inbred mouse strains and how gene expression in these strains is affected by high-fat diet. LG/J and SM/J are known to differ in their responses to a high-fat diet for a variety of obesity- and diabetes-related traits, with the SM/J strain exhibiting a stronger phenotypic response to diet.

Results

Dietary intake had a significant effect on gene

SUBMITTER: Partridge CG 

PROVIDER: S-EPMC4028868 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature