Comparing DNA integration site clusters with scan statistics.

ABSTRACT:

Motivation

Gene therapy with retroviral vectors can induce adverse effects when those vectors integrate in sensitive genomic regions. Retroviral vectors are preferred that target sensitive regions less frequently, motivating the search for localized clusters of integration sites and comparison of the clusters formed by integration of different vectors. Scan statistics allow the discovery of spatial differences in clustering and calculation of false discovery rates providing statistical methods for comparing retroviral vectors.

Results

A scan statistic for comparing two vectors using multiple window widths is proposed with software to detect clustering differentials and compute false discovery rates. Application to several sets of experimentally determined HIV integration sit

SUBMITTER: Berry CC 

PROVIDER: S-EPMC4029028 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature