A comparative study of renal function in male and female spiny mice - sex specific responses to a high salt challenge.

ABSTRACT:

Background

There is a significant body of evidence to suggest that hormone levels, receptor density and structural differences between males and females can significantly alter renal hemodynamics. We compared the renal hemodynamic and excretory profile of female and male spiny mice under baseline conditions and in response to a high-NaCl diet.

Methods

Adult male and female spiny mice were fed either a normal or high salt diet for 7 days. Renal excretory profile was obtained from 24 h urine samples, and renal hemodynamic measurements using anaesthetised renal clearance techniques. Kidneys were excised, weighed and frozen for qPCR analysis.

Results

Under basal conditions, conscious and anaesthetised renal functions were similar between male and female spiny mice when ad

SUBMITTER: Dickinson H 

PROVIDER: S-EPMC4029144 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature