Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer.

ABSTRACT:

Background

Genome-wide association studies have identified that genetic variants in 8q24 confer susceptibility to colorectal cancer (CRC). Recently, a novel lncRNA (PRNCR1) that located in the 8q24 was discovered. Single nucleotide polymorphisms (SNPs) in the lncRNAs may influence the process of splicing and stability of mRNA conformation, resulting in the modification of its interacting partners. We hypothesized that SNPs in the lncRNA PRNCR1 may be related to the risk of CRC.

Methods

We conducted a case-control study and genotyped five tag SNPs in the lncRNA PRNCR1 in 908 subjects including 313 cases with CRC and 595 control subjects using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.

Results

In overall analyses, we found that

SUBMITTER: Li L 

PROVIDER: S-EPMC4029281 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature