MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis.

ABSTRACT:

Objective

The SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Studies investigating the association between MDM2 SNP309 polymorphism and endometrial cancer risk reported conflicting results. We performed a meta-analysis of all available studies to explore this association.

Methods

All studies published up to August 2013 on the association between MDM2 SNP309 polymorphism and endometrial cancer risk were identified by searching electronic databases PubMed, Web of Science, EMBASE, and Chinese Biomedical Literature database (CBM). The association between the MDM2 SNP309 polymorphism and endometrial cancer risk was assessed by odds ratios (ORs) together with their 95% confidence interv

SUBMITTER: Peng Q 

PROVIDER: S-EPMC4029393 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature