Inferring protein domains associated with drug side effects based on drug-target interaction network.

ABSTRACT:

Background

Most phenotypic effects of drugs are involved in the interactions between drugs and their target proteins, however, our knowledge about the molecular mechanism of the drug-target interactions is very limited. One of challenging issues in recent pharmaceutical science is to identify the underlying molecular features which govern drug-target interactions.

Results

In this paper, we make a systematic analysis of the correlation between drug side effects and protein domains, which we call "pharmacogenomic features," based on the drug-target interaction network. We detect drug side effects and protein domains that appear jointly in known drug-target interactions, which is made possible by using classifiers with sparse models. It is shown that the inferred pharmacogenomi

SUBMITTER: Iwata H 

PROVIDER: S-EPMC4029543 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature