Dynamic protein interaction modules in human hepatocellular carcinoma progression.

ABSTRACT:

Background

Gene expression profiles have been frequently integrated with the human protein interactome to uncover functional modules under specific conditions like disease state. Beyond traditional differential expression analysis, differential co-expression analysis has emerged as a robust approach to reveal condition-specific network modules, with successful applications in a few human disease studies. Hepatocellular carcinoma (HCC), which is often interrelated with the Hepatitis C virus, typically develops through multiple stages. A comprehensive investigation of HCC progression-specific differential co-expression modules may advance our understanding of HCC's pathophysiological mechanisms.

Results

Compared with differentially expressed genes, differentially co-expressed

SUBMITTER: Yu H 

PROVIDER: S-EPMC4029569 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature