Up-regulation of CLDN1 in gastric cancer is correlated with reduced survival.

ABSTRACT:

Background

The genetic changes in gastric adenocarcinoma are extremely complex and reliable tumor markers have not yet been identified. There are also remarkable geographical differences in the distribution of this disease. Our aim was to identify the most differentially regulated genes in 20 gastric adenocarcinomas from a Norwegian selection, compared to matched normal mucosa, and we have related our findings to prognosis, survival and chronic Helicobacter pylori infection.

Methods

Biopsies from gastric adenocarcinomas and adjacent normal gastric mucosa were obtained from 20 patients immediately following surgical resection of the tumor. Whole genome, cDNA microarray analysis was performed on the RNA isolated from the sample pairs to compare the gene expression profiles bet

SUBMITTER: Eftang LL 

PROVIDER: S-EPMC4029627 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature