Fetal exposure to maternal inflammation does not affect postnatal development of genetically-driven ileitis and colitis.

ABSTRACT:

Background

Chronic inflammatory disorders have been increasing in incidence over the past decades following geographical patterns of industrialization. Fetal exposure to maternal inflammation may alter organ functions and the offspring's disease risk. We studied the development of genetically-driven ileitis and colitis in response to maternal inflammation using mouse models.

Methods

Disease susceptible (TnfΔARE/+ and IL10-/-) and disease-free (Tnf+/+ and IL10-/+) offspring were raised in inflamed and non-inflamed dams. Ileal, caecal and colonic pathology was evaluated in the offspring at 8 or 12 weeks of age. Ly6G-positive cells in inflamed sections from the distal ileum and distal colon were analysed by immunofluorescence microscopy. Gene expression of pro-inflammatory cyto

SUBMITTER: Hemmerling J 

PROVIDER: S-EPMC4029898 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature