Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model.

ABSTRACT:

Background

Osteosarcomas are the most common primary malignant tumors of bone, showing complex chromosomal rearrangements with multiple gains and losses. A frequent deletion within the chromosomal region 3q13.31 has been identified by us and others, and is mainly reported to be present in osteosarcomas. The purpose of the study was to further characterize the frequency and the extent of the deletion in an extended panel of osteosarcoma samples, and the expression level of the affected genes within the region. We have identified LSAMP as the target gene for the deletion, and have studied the functional implications of LSAMP-reexpression.

Methods

LSAMP copy number, expression level and protein level were investigated by quantitative PCR and western blotting in an osteosarcoma

SUBMITTER: Baroy T 

PROVIDER: S-EPMC4029956 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature