Impaired frontal-basal ganglia connectivity in adolescents with internet addiction.

ABSTRACT: Understanding the neural basis of poor impulse control in Internet addiction (IA) is important for understanding the neurobiological mechanisms of this syndrome. The current study investigated how neuronal pathways implicated in response inhibition were affected in IA using a Go-Stop paradigm and functional magnetic resonance imaging (fMRI). Twenty-three control subjects aged 15.2±0.5 years (mean±S.D.) and eighteen IA subjects aged 15.1±1.4 years were studied. Effective connectivity within the response inhibition network was quantified using (stochastic) dynamic causal modeling (DCM). The results showed that the indirect frontal-basal ganglia pathway was engaged by response inhibition in healthy subjects. However, we did not detect any equivalent effective connectivity in the IA group. Thi

SUBMITTER: Li B 

PROVIDER: S-EPMC4030253 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature