Long Noncoding RNAs in Interaction With RNA Binding Proteins in Hepatocellular Carcinoma.

ABSTRACT:

Background

Gene expression microarrays' analyses provide a description of long noncoding RNAs (lncRNAs) with lack of coding protein function that is often important in human cancer.

Objectives

A number of lncRNAs that have been well characterized in hepatocellular carcinoma (HCC) have been scheduled in this study to discuss for protein-lncRNA interaction.

Materials and methods

The identified lncRNAs were analyzed by bioinformatics tools, starBase and lncRNA db, to anticipate the RNA-binding proteins (RBPs) that tend to interact to HCC-related lncRNAs. The most important predicted RBPs in interaction with well-known lncRNAs in HCC were briefly discussed.

Results

The lncRNAs HOTTIP, H19, HOTAIR, MALAT1, antisense Igf2r (AIR), HOXA13, GTL2 (also called MEG3) and u

SUBMITTER: Mohamadkhani A 

PROVIDER: S-EPMC4030262 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature