Altered oral viral ecology in association with periodontal disease.

ABSTRACT:

Unlabelled

The human oral cavity is home to a large and diverse community of viruses that have yet to be characterized in patients with periodontal disease. We recruited and sampled saliva and oral biofilm from a cohort of humans either periodontally healthy or with mild or significant periodontal disease to discern whether there are differences in viral communities that reflect their oral health status. We found communities of viruses inhabiting saliva and the subgingival and supragingival biofilms of each subject that were composed largely of bacteriophage. While there were homologous viruses common to different subjects and biogeographic sites, for most of the subjects, virome compositions were significantly associated with the oral sites from which they were derived. The larges

SUBMITTER: Ly M 

PROVIDER: S-EPMC4030452 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature