Coordinating bacterial cell division with nutrient availability: a role for glycolysis.

ABSTRACT:

Unlabelled

Cell division in bacteria is driven by a cytoskeletal ring structure, the Z ring, composed of polymers of the tubulin-like protein FtsZ. Z-ring formation must be tightly regulated to ensure faithful cell division, and several mechanisms that influence the positioning and timing of Z-ring assembly have been described. Another important but as yet poorly understood aspect of cell division regulation is the need to coordinate division with cell growth and nutrient availability. In this study, we demonstrated for the first time that cell division is intimately linked to central carbon metabolism in the model Gram-positive bacterium Bacillus subtilis. We showed that a deletion of the gene encoding pyruvate kinase (pyk), which produces pyruvate in the final reaction of glycoly

SUBMITTER: Monahan LG 

PROVIDER: S-EPMC4030479 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature