Global adaptation to a lipid environment triggers the dormancy-related phenotype of Mycobacterium tuberculosis.

ABSTRACT:

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Strong evidence supports the idea that fatty acids rather than carbohydrates are the main energy source of Mycobacterium tuberculosis during infection and latency. Despite that important role, a complete scenario of the bacterium's metabolism when lipids are the main energy source is still lacking. Here we report the development of an in vitro model to analyze adaptation of M. tuberculosis during assimilation of long-chain fatty acids as sole carbon sources. The global lipid transcriptome revealed a shift toward the glyoxylate cycle, the overexpression of main regulators whiB3, dosR, and Rv0081, and the increased expression of several genes related to reductive stress. Our evidence showed that lipid storage seems to be the selected mechanism used by M. tuberculosis to am

SUBMITTER: Rodriguez JG 

PROVIDER: S-EPMC4030484 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature