Automated ensemble assembly and validation of microbial genomes.

ABSTRACT:

Background

The continued democratization of DNA sequencing has sparked a new wave of development of genome assembly and assembly validation methods. As individual research labs, rather than centralized centers, begin to sequence the majority of new genomes, it is important to establish best practices for genome assembly. However, recent evaluations such as GAGE and the Assemblathon have concluded that there is no single best approach to genome assembly. Instead, it is preferable to generate multiple assemblies and validate them to determine which is most useful for the desired analysis; this is a labor-intensive process that is often impossible or unfeasible.

Results

To encourage best practices supported by the community, we present iMetAMOS, an automated ensemble assembly p

SUBMITTER: Koren S 

PROVIDER: S-EPMC4030574 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature