Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA.

ABSTRACT:

Objectives

All HIV/hepatitis C virus (HCV)-coinfected patients with chronic HCV infection and ? F2 fibrosis should be considered for HCV therapy. This study aimed to determine the rate of HCV treatment uptake among coinfected patients in Europe.

Methods

EuroSIDA patients with viraemic HCV infection were included in the study. Poisson regression was used to identify temporal changes and regional differences in HCV treatment uptake.

Results

A total of 1984 patients were included in the study, with a median follow-up time of 168 months [interquartile range (IQR) 121-204 months]. To date, 501 (25.3%) HIV/HCV-coinfected patients have received HCV therapy. Treatment incidence rose from 0.33 [95% confidence interval (CI) 0.16-0.50] per 100 person-years of follow-up (PYFU) in 1998 to 5.93 (95% CI 4.49-7.38) in 2007, falling to 3.78 (95% CI 2.50-5.07) in 2009. After adjustment, CD4 cell count >?350?cells/?L [incidence rate ratio (IRR) 1.33 (95% CI 1.06-1.67) vs.?CD4 count 200-350 cells/?L] and ?F2 liver fibrosis [IRR 1.60 (95% CI 1.14-2.25; P?=?0.0065) vs. ConclusionsAlthough treatment incidence for HCV has increased, there remain a large proportion of patients indicated for treatment who have yet to be treated.

SUBMITTER: Grint D 

PROVIDER: S-EPMC4030620 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature