Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin.

ABSTRACT: Huntington disease (HD) is a debilitating neurodegenerative disease characterized by the loss of motor control and cognitive ability that ultimately leads to death. It is caused by the expansion of a polyglutamine tract in the huntingtin (HTT) protein, which leads to aggregation of the protein and eventually cellular death. Both the wild-type and mutant form of the protein are highly regulated by post-translational modifications including proteolysis, palmitoylation and phosphorylation. We now demonstrate the existence of a new post-translational modification of HTT: the addition of the 14 carbon fatty acid myristate to a glycine residue exposed on a caspase-3-cleaved fragment (post-translational myristoylation) and that myristoylation of this fragment is altered in a physiologically relev

SUBMITTER: Martin DD 

PROVIDER: S-EPMC4030772 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature