Neuronal growth on L- and D-cysteine self-assembled monolayers reveals neuronal chiral sensitivity.

ABSTRACT: Studying the interaction between neuronal cells and chiral molecules is fundamental for the design of novel biomaterials and drugs. Chirality influences all biological processes that involve intermolecular interaction. One common method used to study cellular interactions with different enantiomeric targets is the use of chiral surfaces. Based on previous studies that demonstrated the importance of cysteine in the nervous system, we studied the effect of L- and D-cysteine on single neuronal growth. L-Cysteine, which normally functions as a neuromodulator or a neuroprotective antioxidant, causes damage at elevated levels, which may occur post trauma. In this study, we grew adult neurons in culture enriched with L- and D-cysteine as free compounds or as self-assembled monolayers of chiral su

SUBMITTER: Baranes K 

PROVIDER: S-EPMC4030790 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature