In silico screening of the key cellular remodeling targets in chronic atrial fibrillation.

ABSTRACT: Chronic atrial fibrillation (AF) is a complex disease with underlying changes in electrophysiology, calcium signaling and the structure of atrial myocytes. How these individual remodeling targets and their emergent interactions contribute to cell physiology in chronic AF is not well understood. To approach this problem, we performed in silico experiments in a computational model of the human atrial myocyte. The remodeled function of cellular components was based on a broad literature review of in vitro findings in chronic AF, and these were integrated into the model to define a cohort of virtual cells. Simulation results indicate that while the altered function of calcium and potassium ion channels alone causes a pronounced decrease in action potential duration, remodeling of intracellular

SUBMITTER: Koivumaki JT 

PROVIDER: S-EPMC4031057 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature