Genome-wide nucleosome positioning is orchestrated by genomic regions associated with DNase I hypersensitivity in rice.

ABSTRACT: Nucleosome positioning dictates the DNA accessibility for regulatory proteins, and thus is critical for gene expression and regulation. It has been well documented that only a subset of nucleosomes are reproducibly positioned in eukaryotic genomes. The most prominent example of phased nucleosomes is the context of genes, where phased nucleosomes flank the transcriptional starts sites (TSSs). It is unclear, however, what factors determine nucleosome positioning in regions that are not close to genes. We mapped both nucleosome positioning and DNase I hypersensitive site (DHS) datasets across the rice genome. We discovered that DHSs located in a variety of contexts, both genic and intergenic, were flanked by strongly phased nucleosome arrays. Phased nucleosomes were also found to flank DHSs i

SUBMITTER: Wu Y 

PROVIDER: S-EPMC4031139 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature