PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies.

ABSTRACT:

Background

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear chromatin-associated enzyme involved in several important cellular processes, particularly in the DNA repair system. PARP-1 rs1136410: C>T is among the most studied polymorphisms and likely involved in human carcinogenesis. However, results from previous studies are inconclusive. Thus, a meta-analysis was conducted to derive a more precise estimation of the effects of this enzyme.

Methodology and principal findings

A comprehensive search was conducted in the PubMed and EMBASE databases until December 9, 2013. A total of 39 studies with 16,783 cancer cases and 23,063 control subjects were included in the meta-analysis on the basis of the inclusion and exclusion criteria. No significant association between the PARP

SUBMITTER: Qin Q 

PROVIDER: S-EPMC4031170 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature