Dual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm-mosquito interactions.

ABSTRACT:

Background

Parasite biology, by its very nature, cannot be understood without integrating it with that of the host, nor can the host response be adequately explained without considering the activity of the parasite. However, due to experimental limitations, molecular studies of parasite-host systems have been predominantly one-sided investigations focusing on either of the partners involved. Here, we conducted a dual RNA-seq time course analysis of filarial worm parasite and host mosquito to better understand the parasite processes underlying development in and interaction with the host tissue, from the establishment of infection to the development of infective-stage larva.

Methodology/principal findings

Using the Brugia malayi-Aedes aegypti system, we report parasite gene t

SUBMITTER: Choi YJ 

PROVIDER: S-EPMC4031193 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature