Pandemic H1N1 virus transmission and shedding dynamics in index case households of a prospective Vietnamese cohort.

ABSTRACT:

Objectives

Influenza household transmission studies are required to guide prevention strategies but most passively recruit index cases that seek healthcare. We investigated A(H1N1)pdm09 transmission in a household-based cohort during 2009.

Methods

Health-workers visited 270 households weekly, and collected swabs from influenza-like-illness cases. If A(H1N1)pdm09 was RT-PCR-confirmed, all household members had symptoms assessed and swabs collected daily for 10-15 days. Viral RNA was quantified and sequenced and serology performed on pre-pandemic sera.

Results

Index cases were detected in 20 households containing 81 people. 98.5% lacked A(H1N1)pdm09 neutralizing antibodies in pre-pandemic sera. Eleven (18.6%, 95% CI 10.7-30.4%) of 59 contacts were infected. Virus geneti

SUBMITTER: Thai PQ 

PROVIDER: S-EPMC4031397 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature