An evolutionarily biased distribution of miRNA sites toward regulatory genes with high promoter-driven intrinsic transcriptional noise.

ABSTRACT:

Background

miRNAs are a major class of regulators of gene expression in metazoans. By targeting cognate mRNAs, miRNAs are involved in regulating most, if not all, biological processes in different cell and tissue types. To better understand how this regulatory potential is allocated among different target gene sets, we carried out a detailed and systematic analysis of miRNA target sites distribution in the mouse genome.

Results

We used predicted conserved and non-conserved sites for 779 miRNAs in 3' UTR of 18440 genes downloaded from TargetScan website. Our analysis reveals that 3' UTRs of genes encoding regulatory proteins harbor significantly greater number of miRNA sites than those of non-regulatory, housekeeping and structural, genes. Analysis of miRNA sites for ortholog

SUBMITTER: Zare H 

PROVIDER: S-EPMC4031498 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature