A whole genome SNP genotyping by DNA microarray and candidate gene association study for kidney stone disease.

ABSTRACT:

Background

Kidney stone disease (KSD) is a complex disorder with unknown etiology in majority of the patients. Genetic and environmental factors may cause the disease. In the present study, we used DNA microarray to genotype single nucleotide polymorphisms (SNP) and performed candidate gene association analysis to determine genetic variations associated with the disease.

Methods

A whole genome SNP genotyping by DNA microarray was initially conducted in 101 patients and 105 control subjects. A set of 104 candidate genes reported to be involved in KSD, gathered from public databases and candidate gene association study databases, were evaluated for their variations associated with KSD.

Results

Altogether 82 SNPs distributed within 22 candidate gene regions showed signif

SUBMITTER: Rungroj N 

PROVIDER: S-EPMC4031563 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature