Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction.

ABSTRACT:

Background

Genetic polymorphisms may affect the balance between coagulation and fibrinolysis and thereby affect individual vulnerability to acute myocardial infarction (MI) among patients with underlying coronary atherosclerosis.

Methods

We enrolled 1375 patients with an initial clinical presentation of coronary disease. We genotyped 49 single nucleotide polymorphisms (SNPs) in 9 coagulation system genes and compared patients who had an initial acute MI with patients who presented with stable exertional angina.

Results

An SNP in CD36 (rs3211956) was significantly (P = .04) more common among patients who presented with acute MI (minor allele frequency 10.5%) than patients with stable exertional angina (minor allele frequency 8.0%). This association became marginally si

SUBMITTER: Knowles JW 

PROVIDER: S-EPMC4031914 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature