Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma.

ABSTRACT:

Background

Squamous cell carcinoma of the oral cavity (OSCC) is a common cancer form with relatively low 5-year survival rates, due partially to late detection and lack of complementary molecular markers as targets for treatment. Molecular profiling of head and neck cancer has revealed biological similarities with basal-like breast and lung carcinoma. Recently, we showed that 16 genes were consistently altered in invasive breast tumors displaying varying degrees of aggressiveness.

Methods

To extend our findings from breast cancer to another cancer type with similar characteristics, we performed an integrative analysis of transcriptomic and proteomic data to evaluate the prognostic significance of the 16 putative breast cancer-related biomarkers in OSCC using independent micr

SUBMITTER: Parris TZ 

PROVIDER: S-EPMC4031971 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature