Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancer.

ABSTRACT:

Objective

To evaluate the ability of epithelial-to-mesenchymal transition-related microRNAs (miRNAs) as serum biomarkers for prognosis and prediction of metastasis in patients with colorectal cancer (CRC).

Background

Epithelial-to-mesenchymal transition-related miRNAs drive CRC progression and metastasis. However, their potential as serum biomarkers in CRC has not been studied.

Methods

This was a 3-phase study using 446 colorectal specimens. In the first phase, we selected candidate miRNAs associated with metastasis by analyzing the expression of 4 miR-200 family members (miR-200b, -200c, -141, and -429) in serum samples from 12 patients with stage I and IV CRC. The second phase involved independent validation of candidate miRNAs in serum from 182 patients with CRC an

SUBMITTER: Toiyama Y 

PROVIDER: S-EPMC4032090 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature