Architecture of the superintegron in Vibrio cholerae: identification of core and unique genes.

ABSTRACT:

Background

Vibrio cholerae, the etiologic agent of cholera, is indigenous to aquatic environments. The V. cholerae genome consists of two chromosomes; the smallest of these harbors a large gene capture and excision system called the superintegron (SI), of ~120 kbp. The flexible nature of the SI that results from gene cassette capture, deletion and rearrangement is thought to make it a hotspot of V. cholerae diversity, but beyond the basic structure it is not clear if there is a core genome in the SI and if so how it is structured. The aim of this study was to explore the core genome structure and the differences in gene content among strains of V. cholerae.

Methods

From the complete genomes of seven V. cholerae and one Vibrio mimicus representative strains, we recovered the

SUBMITTER: Marin MA 

PROVIDER: S-EPMC4032106 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature