Plasma FGF23 and the risk of stroke: the Northern Manhattan Study (NOMAS).

ABSTRACT:

Objective

To examine fibroblast growth factor 23 (FGF23) as a risk factor for incident stroke in a racially/ethnically diverse population-based urban cohort.

Methods

Stroke-free Northern Manhattan Study participants with FGF23 measurements (n = 2,525) were followed for a mean of 12 (±5) years to detect incident strokes. We used Cox proportional hazards models to estimate the association of baseline FGF23 with incident total, ischemic, and hemorrhagic stroke.

Results

Median FGF23 was 57 relative units (RU)/mL (interquartile range = 44-81 RU/mL). Each unit increase of natural log-transformed FGF23 conferred a 40% greater overall stroke risk after adjusting for estimated glomerular filtration rate and sociodemographic and vascular risk factors (hazard ratio = 1.4, 95% co

SUBMITTER: Wright CB 

PROVIDER: S-EPMC4032206 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature