Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy.

ABSTRACT:

Objective

A significant cause of spontaneous hemorrhages in the elderly is cerebral amyloid angiopathy (CAA), which causes degeneration of cerebral vessels, but the mechanisms are unclear.

Methods

We isolated leptomeningeal vessels from rapidly autopsied brains (the average of postmortem intervals was 3.28 hours) from 9 patients with CAA and 10 age-matched controls, and used molecular, cell biology, and immunohistochemical approaches to examine β-site APP-cleaving enzyme 1 (BACE1) protein expression and enzymatic activities as well as tight junction molecular components in small- and medium-sized arteries of the cerebral cortex and leptomeninges.

Results

We not only identified that the cerebral vessels, including leptomeningeal and cortical vessels, synthesize and exp

SUBMITTER: Cheng X 

PROVIDER: S-EPMC4032211 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature