Acute HIV-1 infection is as common as malaria in young febrile adults seeking care in coastal Kenya.

ABSTRACT:

Background

Febrile adults are usually not tested for acute HIV-1 infection (AHI) in Africa. We assessed a strategy to diagnose AHI among young adult patients seeking care.

Methods

Young adults (<30 years) who met predefined AHI criteria at care seeking, including fever, sexually transmitted disease symptoms, diarrhoea, body pains or multiple partners were referred from five pharmacies and screened at five health facilities. Prevalent HIV-1 was diagnosed by nationally recommended serial rapid HIV-1 testing. Willing HIV-1-negative patients were evaluated for AHI, defined as a positive p24 antigen test, and subsequent seroconversion or RNA detection. Febrile patients evaluated for AHI were also screened for malaria using a rapid test, with PCR confirmation of positives.

Resu

SUBMITTER: Sanders EJ 

PROVIDER: S-EPMC4032215 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature