Local gyrification index in probands with psychotic disorders and their first-degree relatives.

ABSTRACT:

Background

Psychotic disorders are characterized by aberrant neural connectivity. Alterations in gyrification, the pattern and degree of cortical folding, may be related to the early development of connectivity. Past gyrification studies have relatively small sample sizes, yield mixed results for schizophrenia, and are scant for psychotic bipolar and schizoaffective (SZA) disorders and for relatives of these conditions. Here, we examine gyrification in psychotic disorder patients and their first-degree relatives as a possible endophenotype.

Methods

Regional local gyrification index (LGI) values, as measured by FreeSurfer software, were compared between 243 control subjects, 388 psychotic disorder probands, and 300 of their first-degree relatives. For patients, LGI values wer

SUBMITTER: Nanda P 

PROVIDER: S-EPMC4032376 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature