Natural variation of histone modification and its impact on gene expression in the rat genome.

ABSTRACT: Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. Little is known about interindividual variability of histone modification levels across the genome and to what extent they are influenced by genetic variation. We annotated the rat genome with histone modification maps, identified differences in histone trimethyl-lysine levels among strains, and described their underlying genetic basis at the genome-wide scale using ChIP-seq in heart and liver tissues in a panel of rat recombinant inbred and their progenitor strains. We identified extensive variation of histone methylation levels among individuals and mapped hundreds of underlying cis- and trans-acting loci throughout

SUBMITTER: Rintisch C 

PROVIDER: S-EPMC4032858 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature