Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding.

ABSTRACT:

Objectives

Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations.

Design

We used functional MRI, eating behaviour and hormonal phenotyping to compare body mass index (BMI)-matched unoperated controls and patients after RYGB and BAND surgery for obesity.

Results

Obese patients after RYGB had lower brain-hedonic responses to food than patients after BAND surgery. RYGB patients had lower activation than BAND patients in brain reward systems, particularly to high-calorie foods, including the orbitofrontal cortex, amygdala, caudate nucleus, nucleus accumben

SUBMITTER: Scholtz S 

PROVIDER: S-EPMC4033279 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature