IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells.

ABSTRACT:

Background

Asthma is a predominantly TH2 cell-dominated inflammatory disease characterized by airway inflammation and a major public health concern affecting millions of persons. The Tec family tyrosine kinase IL-2-inducible T-cell kinase (Itk) is primarily expressed in T cells and critical for the function and differentiation of TH cells. Itk(-/-) mice have a defective TH2 response and are not susceptible to allergic asthma.

Objective

We sought to better understand the role of Itk signaling in TH differentiation programs and in the development and molecular pathology of allergic asthma.

Methods

Using a murine model of allergic airway inflammation, we dissected the role of Itk in regulating TH cell differentiation through genetic ablation of critical genes, chromatin

SUBMITTER: Kannan AK 

PROVIDER: S-EPMC4033298 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature