Network of microRNAs-mRNAs interactions in pancreatic cancer.

ABSTRACT:

Background

MicroRNAs are small RNA molecules that regulate the expression of certain genes through interaction with mRNA targets and are mainly involved in human cancer. This study was conducted to make the network of miRNAs-mRNAs interactions in pancreatic cancer as the fourth leading cause of cancer death.

Methods

56 miRNAs that were exclusively expressed and 1176 genes that were downregulated or silenced in pancreas cancer were extracted from beforehand investigations. MiRNA-mRNA interactions data analysis and related networks were explored using MAGIA tool and Cytoscape 3 software. Functional annotations of candidate genes in pancreatic cancer were identified by DAVID annotation tool.

Results

This network is made of 217 nodes for mRNA, 15 nodes for miRNA, and 241

SUBMITTER: Naderi E 

PROVIDER: S-EPMC4033392 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature